منابع مشابه
Evolution of voltage-gated Na(+) channels.
Voltage-gated Na(+) channels play important functional roles in the generation of electrical excitability in most vertebrate and invertebrate species. These channels are members of a superfamily that includes voltage-gated K(+), voltage-gated Ca(2+) and cyclic-nucleotide-gated channels. There are nine genes encoding voltage-gated Na(+) channels in mammals, with a tenth homologous gene that has ...
متن کاملCalmodulin and Ca2+ control of voltage gated Na+ channels
The structures of the cytosolic portion of voltage activated sodium channels (CTNav) in complexes with calmodulin and other effectors in the presence and the absence of calcium provide information about the mechanisms by which these effectors regulate channel activity. The most studied of these complexes, those of Nav1.2 and Nav1.5, show details of the conformations and the specific contacts th...
متن کاملLocalization and Distribution of Voltage-Gated Na Channels
There are nine recognized members of the voltage-gated Na+ channel family (VGSC; Nav1.1Nav1.9). Of these, Nav1.1, Nav1.2, Nav1.3 and Nav1.6 are highly (but not exclusively) expressed in the central nervous system (CNS), whereas Nav1.7, Nav1.8 and Nav1.9 demonstrate a more restricted expression pattern in autonomic and sensory neurons of the peripheral nervous system (PNS). Nav1.4 and Nav1.5 rep...
متن کاملVOLTAGE-GATED ION CHANNELS Voltage-Gated Sodium Channels
Antiepileptic drugs (AEDs) protect against seizures through interactions with a variety of cellular targets. By affecting the functional activity of these targets, AEDs suppress abnormal hypersynchronous activity in brain circuits, leading to protection against seizures. The actions on these targets can be categorized into four broad groups: (i) modulation of voltage-gated ion channels, includi...
متن کاملClustered voltage-gated Na+ channels in Aplysia axons.
Clustering of voltage-gated Na+ channels is critical for the fast saltatory conduction of action potentials in vertebrate myelinated axons. However, the mechanisms responsible for the generation and maintenance of Na+ channel clustering are not well understood. In this study we have raised an antibody against the cloned SCAP-1 voltage-gated Na+ channel of the marine invertebrate Aplysia califor...
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ژورنال
عنوان ژورنال: Epilepsia
سال: 2010
ISSN: 0013-9580
DOI: 10.1111/j.1528-1167.2010.02795.x